Evidence That Control of Fetal Thyrotropin Secretion is Independent of Both the Fetal and Maternal Hypothalamus*
- 1 March 1978
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 102 (3) , 852-858
- https://doi.org/10.1210/endo-102-3-852
Abstract
Propylthiouracil (PTU) administered to pregnant rats from day 18-21 of gestation caused a significant increase in maternal and fetal thyroid weight and plasma TSH [thyroid stimulating hormone]. Fetal encephalectomy on day 18 did not significantly affect basal or PTU-stimulated pituitary-thyroid function. Destruction of the basal hypothalamus in the mother on day 13 or 16 markedly reduced maternal plasma TSH and thyroxine and prevented a PTU-induced increase in thyroid size, but did not affect fetal pituitary-thyroid function. Plasma. PRL [prolactin] was undetectable in both intact and encephalectomized fetuses at 21 days but was increased > 6-fold to approximately 2 .mu.g/ml in the mothers by maternal hypothalamic destruction. Fetal pituitary-thyroid function in the rat was not dependent on either fetal or maternal hypothalam TRH [thyroid releasing hormone].This publication has 1 reference indexed in Scilit:
- PLACENTAL TRANSFER OF THYROTROPIC HORMONE, THYROXINE, TRIIODOTHYRONINE, AND INSULIN IN THE RAT*Annals of the New York Academy of Sciences, 1959