Single DNA Rotaxanes of a Transmembrane Pore Protein
- 1 June 2004
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 43 (23) , 3063-3067
- https://doi.org/10.1002/anie.200453907
Abstract
Threading a molecular needle: An α‐hemolysin transmembrane pore can be threaded in a desired orientation by DNA–poly(ethylene glycol) (DNA‐PEG) hybrid strands to yield functional rotaxanes (see figure). The single‐molecule rotaxanes are stable and have a reversible two‐state switching capacity that depends on the applied potential, orientation, and method of threading and capture used.Keywords
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