Effect of Verapamil on Frequency-Force Relationship in Isolated Dog Left Ventricular Muscle
Open Access
- 1 January 1977
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 27 (1) , 175-177
- https://doi.org/10.1254/jjp.27.175
Abstract
A relatively small dose of verapamil, 1-100 .mu.g, did not influence the developed tension at 0.5 Hz. The tension at a higher freqeuncy of 1, 2 or 3 Hz was markedly depressed. Even a larger dose of verapamil caused much greater suppression at higher frequencies. Manganese chloride at 1-10 mg caused a rather uniform depression of the developed tension at 0.5, 1, 2 and 3 Hz in 3 experiments.This publication has 4 references indexed in Scilit:
- Inotropic and electrophysiological actions of verapamil and D600 in mammalian myocardiumNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1975
- Muscarinic suppression of the nicotinic action of acetylcholine on the isolated, blood-perfused atrium of the dogNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1975
- Comparison of the Effects of Norepinephrine and Acetylcholine Between Intraarterial and Extravascular Administration to the Isolated, Blood-Perfused Canine AtriumThe Japanese Journal of Pharmacology, 1975
- FREQUENCY-FORCE RELATIONSHIP IN THE BLOOD-PERFUSED CANINE PAPILLARY MUSCLE PREPARATIONThe Japanese Journal of Physiology, 1970