Induction of Interferon in Human Lymphoblastoid Cells by Sendai and Measles Viruses

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Abstract
Sendai and measles viruses were tested for their interferon-inducing capacity in human lymphoblast cells. Sendai virus reproducibly induced considerable amounts of interferon (1 research reference interferon unit/103 cells), but no increase in infectious virus titer was observed. Two Edmonston-Enders [EE] strains of measles virus grew very well. The attenuated (A) strain was a good interferon inducer (4 units/103 cells), while the virulent (V) strain induced only minimal amounts at a high multiplicity of infection. Pre-treatment of the cells with 5-iododeoxyuridine (IdUrd) had no effect on the growth of Sendai or EE measles virus and on interferon yields induced by Sendai virus. It slightly potentiated interferon induction by EE measles virus. Partial UV-light-inactivation of Sendai virus infectivity resulted in a parallel loss in interferon-inducing capacity.