Effect of exogenous mouse interferon on murine fulminant hepatitis induced by mouse hepatitis virus type 2
- 1 February 1986
- journal article
- research article
- Published by Springer Nature in Digestive Diseases and Sciences
- Vol. 31 (2) , 177-180
- https://doi.org/10.1007/bf01300705
Abstract
We investigated the effect of exogenous mouse α-+β-interferon produced by mouse L cells on the growth of mouse hepatitis virus type 2 (MHV-2) in the liver, the development of liver cell necrosis, and survival in murine fulminant hepatitis induced by MHV-2. Murine fulminant hepatitis was induced in 4-week-old male ICR mice by intraperitoneal inoculation of MHV-2. Mouse interferon (103 IU/mouse/day) was intraperitoneally injected every day. Exogenous mouse interferon suppressed both the growth of MHV-2 in the liver tissue and development of liver cell necrosis, and prolonged the survival. It was also found that the earlier mouse interferon was administered, the greater was the prolongation of survival.Keywords
This publication has 15 references indexed in Scilit:
- The Effect of Mouse Hepatitis Virus Infection on the Microcirculation of the LiverHepatology, 1983
- Activation of natural killer cells and induction of interferon after injection of mouse hepatitis virus type 3 in miceInfection and Immunity, 1982
- INTERFERON SYSTEM IN ACUTE VIRAL HEPATITISThe Lancet, 1982
- Lymphocyte-instructed monocyte induction of the coagulation pathways parallels the induction of hepatitis by the murine hepatitis virus.1982
- Comparison of mouse hepatitis virus strains for pathogenicity in weanling mice infected by various routesArchiv für die gesamte Virusforschung, 1981
- Blocking of in vitro and in vivo susceptibility to mouse hepatitis virus.The Journal of Experimental Medicine, 1977
- Difference in Response to Mouse Hepatitis Virus among Susceptible Mouse StrainsJapanese Journal of Microbiology, 1976
- Replication and plaque formation of mouse hepatitis virus (MHV-2) in mouse cell line DBT cultureArchiv für die gesamte Virusforschung, 1974
- A generalized Wilcoxon test for comparing arbitrarily singly-censored samplesBiometrika, 1965
- MOUSE MACROPHAGES AS HOST CELLS FOR THE MOUSE HEPATITIS VIRUS AND THE GENETIC BASIS OF THEIR SUSCEPTIBILITYProceedings of the National Academy of Sciences, 1960