Structural wrinkles and the genomic regulatory sites of eukaryotes
- 1 October 1985
- journal article
- research article
- Published by Springer Nature in Journal of Molecular Evolution
- Vol. 22 (2) , 150-159
- https://doi.org/10.1007/bf02101693
Abstract
Calculations of DNA angular parameters in 50 eukaryotic sequences reveal regions of large conformational deviations from ideal DNA around regulatory sites. Frequently, discrete peaks of structural variation are present upstream of genes. Known regulatory regions often include variants of consensus sequences. Thus, imprecise sequences and structures are recognized within large genomic stretches. The existence of structurally “wrinkled” regions in the vicinity of regulatory sequences is likely to facilitate greatly their recognition by proteins and enzymes.This publication has 65 references indexed in Scilit:
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