Excipients in Valproic Acid Syrup May Cause Diarrhea: A Case Report
- 1 September 1990
- journal article
- research article
- Published by SAGE Publications in DICP
- Vol. 24 (9) , 832-833
- https://doi.org/10.1177/106002809002400907
Abstract
A 5-year-old child receiving valproic acid syrup for seizure control developed diarrhea probably from the excipient ingredients. Each 5 mL of valproic acid syrup contains sucrose 3 g, glycerin 0.75 g sorbitol 0.75 g, providing daily amounts of 36, 9 9 g of sucrose, glycerin sorbitol, respectively. The diarrhea resolved when the child was switched to another valproic acid product. Clinicians should be aware of potential problems that may occur from excipient ingredients in pharmaceutical products when evaluating adverse effects of medications.This publication has 7 references indexed in Scilit:
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