Analysis of the Mouse Transcriptome for Genes Involved in the Function of the Nervous System
Open Access
- 2 June 2003
- journal article
- Published by Cold Spring Harbor Laboratory in Genome Research
- Vol. 13 (6b) , 1395-1401
- https://doi.org/10.1101/gr.1135303
Abstract
We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function.We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including Family 3 G-protein coupled receptors, voltage-gated channels, and connexins.We also identified previously unknown candidates for secreted neuroactive molecules.The existence of a large number of unique brain ESTs suggests an additional molecular complexity that remains to be explored.A list of genes containing CAG stretches in the coding region represents a first step in the potential identification of candidates for hereditary neurological disorders.Keywords
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