The Safety Profile of De-Nol®

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Abstract
The safety profile of colloidal bismuth subcitrate (CBS, De-Nol®) is reviewed in the light of the situation surrounding bismuth-containing preparations in general. The unique outbreak of bismuth intoxication which occurred in France in the previous decade is examined and an attempt is made to explain it. The conclusion is drawn that the misuse of bismuth salts, which were taken in very large quantities and for prolonged periods, was very likely the responsible factor. Unlike the preparations involved with neurotoxicity in France, CBS complies in every respect to the present requirements for a modern drug. CBS is a potent peptic ulcer-healing agent acting at the level of mucosal defense. Side effects so far reported both in clinical trials and from practising physicians have been very infrequent, mild and transient.

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