EFFECTS OF IRON-DEFICIENCY ON ABSORPTION AND DISTRIBUTION OF LEAD AND CADMIUM IN RATS

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 90  (4) , 700-706
Abstract
To evaluate the effects of Fe deficiency on the absorption of pollutant metals, an Fe-deficient diet was fed to young rats until their tissue-Fe stores were depleted. Prior to the development of anemia, the Fe-deficient rats and littermate controls were administered an intragastric gavage of 210Pb or 109Cd and were killed 48 h later. The body burden of Pb was .apprx. 6 times greater, and that of Cd .apprx. 7 times greater, in Fe-deficient rats than in the controls. No consistent effects were observed on concentration of serum total lipids or serum proteins nor on protein electrophoretic patterns in rats with a deficit in Fe stores.