TREATMENT OF ACUTE POST-OPERATIVE INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION WITH DIPHENYLHYDANTOIN

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Abstract
Post-operative inappropriate antidiuretic hormone (ADH) secretion was observed 6 times in a group of 26 patients without diabetes insipidus before surgery for craniopharyngioma. Fourteen patients with existing diabetes insipidus did not show this disturbance. Intravenous administration of diphenylhydantoin (250 mg q. 8 h) controlled the hyponatraemia during the interphase of abnormal urine concentration and established an increased transitory water excretion in an 8 year old child operated upon for craniopharyngioma.