Effects of cyanide, amytal, and DNP on renal sodium absorption

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Abstract
The effects of cyanide, amytal, and 2,4-dinitrophenol (DNP) on sodium chloride and water absorption were studied In the proximal tubule of the intact rat kidney with the Gertz and Ullrich micropuncture method. Cyanide and amytal markedly decreased absorption, suggesting that the electron transport system may be essential for absorption at a normal rate, and the succinoxidase activity alone is possibly incapable of maintaining this normal rate. Although DNP was less inhibitory than cyanide or amytal, the data indicate that the normal rate of absorption of sodium chloride and water is perhaps dependent on the synthesis of ATP.