Sound‐induced seizures in animals

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Abstract
A Mg deficient diet was used to produce sound-induced seizures in rats. A considerable variation was found in the degree of induced Mg deficiency produced in animals fed the same diet. Serum Mg levels were minimal about 20-30 days after the feeding of the special diet was begun and then gradually rose, but did not return to normal levels even after 50-60 days. The total amount of Mg present in the brain did not change, but Mg deficiency caused a significant deposition of Ca in the kidneys. Associated with Mg deficiency, a slight decrease in muscle Mg and K was noted. Additional Ca supplementation of Mg-deficient animals did not protect them from sound-induced seizures.

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