Multiplication of Lymphocytic Choriomeningitis Virus in Cultivated Foetal Inbred Mouse Cells and in Neonatally Infected Inbred Carrier Mice

Publisher Website
Google Scholar
Abstract
SUMMARY The replication of infectious LCM virus and its complement-fixing antigen was followed in cultivated foetal cells from colony-bred albino mice, foetal cells from CBA/Ca, C3H/HeJ, C57BL/6, and DBA/2 inbred mice, and L cells, Typical S-shaped growth curves were obtained in all instances and yields approached lO 4 intracerebral mouse IDs0/cell. After the infection of newborn mice the multiplying virus rapidly reached a plateau of infectivity in tissues which remained thereafter. Ten weeks after neonatal infection the virus concentrations in blood and organs of ordinary albino mice and of CBA, C3H, C57BL/6, and DBA/2 inbred mice showed a wide range with highest levels in the kidneys and lowest in the blood. The multiplication patterns and maximum yields of infectious virus and com- plement-fixing antigen were essentially identical in L cells and in foetal cells derived from five mouse strains; mutatis mutandis the same was true for persisting virus in the blood and organs of neonatal carrier mice.

This publication has 0 references indexed in Scilit: