Chemosterilant Efficiency of Bis ( l-Aziridinyl) Phosphinyl Carbamates in Screw-Worm Flies2

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Abstract
Antifertility effects were induced in adult screw-worm flies, Cochliomyia hominivorax (Coquerel), treated topically or orally with 4 esters of bis (l-aziridinyl) phosphinyl carbamic acid. The compounds were much less active administered topically than orally. At 1%, uredepa (ethyl [bis (l-aziridinyl) phosphinyl] carbamate), sterilized either sex orally and with little toxicity. Yet uredepa-sterilized males were about half as competitive for mates as normal or gamma-irradiated flies. Flies of either sex were effectively sterilized with uredepa at all ages tested up to 7 days and males remained infertile for life. Inseminated females were rendered sterile when treated with uredepa either before or after depositing fertile eggs. Oral administration of 0.1% uredepa together with a folic acid antagonist was as effective as 1% uredepa alone in obliterating female fertility because of the action of the antagonist, and survival of treated females was improved. Uredepa (0.05%), offered to both sexes orally in a single dose or in 5 equally divided daily fractions, caused incomplete and complete sterility, respectively.

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