Autoreagins and Conventional Autoantibodies to Rabbit Male Accessory Glands Induced by Cryoimmunization

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Abstract
Cryosurgery of rabbit male accessory glands induced the formation of organ-specific hemagglutinating and skin anaphylactic autoantibodies. The latter antibodies appeared to fulfill the criteria for homocytotropic antibodies since they fixed to homologous skin, showed heat lability and were clearly differentiable from IgG and IgM antibody when serum samples were chromatographed through Sephadex G-200 gel column. Using Sephadex G-100 rabbit seminal plasma fractions it was possible to prove that autoantigens and autoallergens are confined in different fractions judging by their capacity to produce positive hemagglutinating and passive cutaneous anaphylaxis reactions. The extrapolation of these results could have important implications in the field of autoimmune diseases.

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