TREATMENT OF EARLY SYPHILIS WITH PENICILLIN

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Abstract
In a previous paper1 we presented the results of the treatment of early syphilis with the twenty-six weeks' oxophenarsine hydrochloride—bismuth schedule which was adopted by the Army in July 1942. It was shown that this schedule was of relatively low toxicity and yielded a high proportion of satisfactory therapeutic results. Its eventual replacement as the standard therapeutic procedure came about mainly because it failed to meet Army requirements for a short intensive schedule for soldiers under field or combat conditions and because of the demonstration that penicillin was a potent antisyphilitic agent. Encouraged by the pioneer experiments of Mahoney, Arnold and Harris,2 the extensive investigations of the Subcommittee on Venereal Disease, National Research Council3 and certain pilot studies within the Army,4 the Surgeon General in 1944, on recommendation of the National Research Council, instituted penicillin treatment for all soldiers with early or latent syphilis. The schedule

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