Identification of Magnolol and Honokiol as Anxiolytic Agents in Extracts of Saiboku-to, an Oriental Herbal Medicine
- 1 January 1998
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 61 (1) , 135-138
- https://doi.org/10.1021/np9702446
Abstract
The principal active anxiolytic components in Saiboku-to, an Oriental herbal medicine, have been isolated and identified as magnolol (5,5‘-di-2-propenyl-1,1‘-biphenyl-2,2‘-diol) and honokiol (3‘,5-di-2-propenyl-1,1‘-biphenyl-2,4‘-diol). Evaluation by means of an elevated plus-maze test showed that honokiol was at least 5000 times more potent than Saiboku-to when mice were treated orally for 7 days.Keywords
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