The binding of tritiated tetrodotoxin to squid giant axons

10 June 1975

journal article
Published by The Royal Society in Philosophical Transactions of the Royal Society of London. B, Biological Sciences

Vol. 270 (908) , 349-352
https://doi.org/10.1098/rstb.1975.0014

Abstract

The binding of tetrodotoxin to squid giant axons was determined as a function of toxin concentration, using a tritiated toxin preparation of known radiochemical purity and specific activity. From the amount of saturable binding observed, the number of toxin binding sites thought to be sodium channels was found to be 553 ± 119/p.m ² of axon surface.

Keywords

FUNCTION
SODIUM
BINDING
AXONS
TETRODOTOXIN
SQUID
GIANT
SATURABLE
TRITIATED
119/P.M