Urinary Ligandin and Glutathione-S-Transferase in Gentamicin-Induced Nephrotoxicity in the Rat
- 1 July 1981
- journal article
- research article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 61 (1) , 123-125
- https://doi.org/10.1042/cs0610123
Abstract
1. Eight rats developed detectable glutathione-S-transferase activity in their urine after three daily injections of toxic doses of gentamicin. 2. Seven of the eight rats had immunodetectable ligandin in their urine at this time. 3. The level of enzyme activity correlated well with the degree of elevation of serum creatinine. 4. This confirms ligandinuria and urinary glutathione-S-transferase as markers of acute renal proximal tubular injury.Keywords
This publication has 2 references indexed in Scilit:
- Ligandinuria in nephrotoxic acute tubular necrosisKidney International, 1977
- Enzymatic Evidence of Renal Tubular Damage Following Renal AngiographyRadiology, 1976