Etiology of Chemically Induced Writhing in Mouse and Rat

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Abstract
An attempt was made to investigate etiology of chemically induced writhing in mouse and rat by the use of phenylquinone, serotonin, histamine, HC1, L 1935, reserpine, NaOH, 48/80, heparin, water, and saline as writhing-inciters and amino-pyrine, morphine, LSD, and chlorpheniramine as blockers of writhing. It is probable that histamine and acidity of injected solution are not etiologic. Release of serotonin or of some hitherto unknown substance, as well as direct irritation of nerve endings, may be causative. Phenylquinone and HC1 appear most useful in screening for analgesics because of smaller possibility of false-positive occurrence.
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