Prenatal diagnosis of alpha‐1‐antitrypsin deficiency by PCR of linked polymorphisms: A study of 17 cases

1 April 1992

journal article
research article
Published by Wiley in Prenatal Diagnosis

Vol. 12 (4) , 235-240
https://doi.org/10.1002/pd.1970120402

Abstract

We describe our experiences of prenatal diagnosis of alpha‐1‐antitrypsin deficiency using closely linked polymorphisms detected by Southern blotting and the polymerase chain reaction. Prenatal diagnosis was carried out for 17 pregnancies from 15 couples.

Keywords

This publication has 11 references indexed in Scilit:

Genetic studies on a new deficiency gene (PI*Ztun) at the PI locus.
Journal of Medical Genetics, 1989
Molecular basis of alpha-1-antitrypsin deficiency
Published by Elsevier ,1988
The human alpha-1-antitrypsin-related sequence gene: isolation and investigation of its expression
Annals of Human Genetics, 1988
PRENATAL DIAGNOSIS OF ALPHA-1-ANTITRYPSIN DEFICIENCY USING POLYMERASE CHAIN REACTION
The Lancet, 1988
A potent inhibitor ofTaqpolymerase copurifies with human genomic DNA
Nucleic Acids Research, 1988
α1-ANTTTRYPSIN-RELATED GENE (ATR) FOR PRENATAL DIAGNOSIS
The Lancet, 1987
Species- and tissue-specific expression of human alpha 1-antitrypsin in transgenic mice.
Genes & Development, 1987
Prenatal diagnosis of alpha‐1‐antitrypsin deficiency by fetal blood sampling
Prenatal Diagnosis, 1987
RESTRICTION ENZYME MaeIII FOR PRENATAL DIAGNOSIS OF $alpha;1-ANTITRYPSIN DEFICIENCY
The Lancet, 1986