Effect of Carbohydrate and Fat Intakes upon the Activities of Several Liver Enzymes in Rats, Guinea Piglets, Piglets and Calves

Publisher Website
Google Scholar
Abstract
The effects of 4 diets containing a wide range of carbohydrate and fat upon the activities of a number of liver enzymes in rats, guinea piglets, calves and piglets were investigated. The results indicated that large adaptive enzymatic changes occurred in rats fed high carbohydrate diets but not in guinea piglets, piglets and calves. The activities of most of the enzymes studied changed in logarithmic relationship to the ratio, carbohydrate calories-to-carbohydrate + fat calories, in the diets indicating that the enzymatic adaptations occurred in response to changes in proportions of energy contributed by carbohydrate and fat rather than to changes in the amounts of these components per se. The results indicated that calves, guinea piglets and piglets have much lower capacities for adaptation to high carbohydrate, low fat diets than rats, due either to species differences in rates of physiological development after birth or to other inherent species differences. The activities of all the enzymes whose functions have been related to fat synthesis were much lower in calves than in rats.