Rapid Assembly of Polycyclic Substances by a Multicomponent Cascade (4 + 2)−(2 + 2) Cycloadditions: Total Synthesis of the Proposed Structure of Paesslerin A

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Abstract
A versatile method for stereoselective formation of multisubstituted bicyclo[4.2.0]octane framework has been developed by means of catalytic (4 + 2)−(2 + 2) cycloaddition reactions. Its application to the synthesis of a substance reported to be the cytotoxic sesquiterpene, paesslerin A, is described, and it has been made clear that a revision of the structure of natural paesslerin A is required.