Characterization of immature CD4+CD8−CD3− thymocytes
- 1 March 1991
- journal article
- Published by Wiley in European Journal of Immunology
- Vol. 21 (3) , 835-838
- https://doi.org/10.1002/eji.1830210346
Abstract
Previously we have described (Hugo, P. et al., Int. Immunol. 1990. 2: 209) an immature CD4+CD8−CD3− thymocyte subset which is thought to be the counterpart of the CD4−CD8+CD3− subset. In this study we show that the ontogeny of these two subsets is parallel in fetal thymic organ culture. Extensive phenotypic characterization of CD4+CD8−CD3− cells reveals that they closely resemble CD4−CD8+CD3− thymocytes being: HSAhigh, Thy‐1high, interleukin 2 receptor α chain negative, CD44−, H2K+/−, CD5low, MEL‐14low/intermediate, CD2+, LFA‐1+ and MTS 35+. Finally, we show that the proportion of CD4+CD8−CD3− thymocytes is highly variable between mouse strains.Keywords
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