Prostaglandin production by the rabbit uterus and placenta in vitro

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Abstract
Endogenous concentrations of prostaglandin (PG) F2.alpha. in the rabbit uterus were higher on day-17 of pseudopregnancy than on days 4, 7 and 11 of pseudopregnancy and day-17 of pregnancy. These differences are consistent with the findings reported previously that the output of PGF2.alpha. from the rabbit uterus is higher on day-17 of pseudopregnancy than on earlier days of pseudopregnancy and day-17 of pregnancy. Uterine homogenates synthesized PG and, of the 3 PG measured, 6-oxo-PGF1.alpha. was the major product. There were no differences in the amounts of any one PG synthesized during pseudopregnancy. Unstretched uterine tissue from day-17-pregnant rabbits produced quantities of PG similar to those of uterine tissue from day-17-pseudopregnant rabbits. Stretched uterine tissue from day-17-pregnant rabbits produced more 6-oxo-PGF1.alpha. and PGE2, but not PGE2.alpha., than did unstretched tissue or pseudopregnant uterine tissue from day-17 rabbits. PG production by the fetal placenta was higher than that by the maternal placenta. PGE2 and 6-oxo-PGF1.alpha. were the major PG produced by the fetal and maternal placentae, respectively. Metabolism of PGF2.alpha. required NAD+ and metabolism by the placenta was greater than that by the uterus. Compounds less polar and more polar than PGF2.alpha. were produced, although the production of more polar metabolites appeared to require a period of progesterone priming of the uterus.

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