Thimet oligopeptidase (EC 3.4.24.15) activates CPI-0004Na, an extracellularly tumour-activated prodrug of doxorubicin
- 30 November 2006
- journal article
- Published by Elsevier in European Journal Of Cancer
- Vol. 42 (17) , 3049-3056
- https://doi.org/10.1016/j.ejca.2005.10.030
Abstract
No abstract availableKeywords
This publication has 23 references indexed in Scilit:
- Multiple pathways of cell invasion are regulated by multiple families of serine proteasesClinical & Experimental Metastasis, 2002
- N-Succinyl-(β-alanyl-l-leucyl-l-alanyl-l-leucyl)doxorubicin: An Extracellularly Tumor-Activated Prodrug Devoid of Intravenous Acute ToxicityJournal of Medicinal Chemistry, 2001
- Unraveling the role of proteases in cancerClinica Chimica Acta; International Journal of Clinical Chemistry, 2000
- Superior therapeutic efficacy of N-l-leucyl-doxorubicin versus doxorubicin in human melanoma xenografts correlates with higher tumour concentrations of free drugEuropean Journal Of Cancer, 1999
- Cloning and Functional Expression of a Metalloendopeptidase from Human Brain with the Ability to Cleave a β-APP Substrate PeptideBiochemical and Biophysical Research Communications, 1995
- Rat thimet oligopeptidase: large-scale expression in Escherichia coli and characterization of the recombinant enzymeBiochemical Journal, 1995
- Characterization of a Mitochondrial Metallopeptidase Reveals Neurolysin as a Homologue of Thimet OligopeptidasePublished by Elsevier ,1995
- Human pharmacokinetics of N-L-leucyl-doxorubicin, a new anthracycline derivative, and its correlation with clinical toxicitiesClinical Pharmacology & Therapeutics, 1992
- Structure/function relationships in the inhibition of thimet oligopeptidase by carboxyphenylpropyl‐peptidesFEBS Letters, 1991
- Substrate-related potent inhibitors of brain metalloendopeptidaseBiochemistry, 1988