Stereospecificity of carbon–sulphur bond formation in penicillin biosynthesis
- 1 January 1986
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 2,p. 110-113
- https://doi.org/10.1039/c39860000110
Abstract
The conversion of the tripeptide (L-α-amino-δ-adipoyl)-L-cysteinyl-D-valine (α-amino-δ-adipoyl = 5-amino-5-carboxypentanoyl) into isopenicillin N by the enzyme isopenicillin N synthetase has been shown to proceed with complete retention of stereochemistry; a similar result was observed during penicillin formation with isoleucinyl and allo-isoleucinyl tripeptides.Keywords
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