Cephalexin dosage in general practice assessed by double-blind trial

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Abstract
In a double-blind multicentre trial conducted in general practice, 851 adult patients were treated with either cephalexin (‘Ceporex’) tablets 250 mg. or 500 mg. q.d.s. for 7 days. The trial included the common infections, excepting pneumonias and sore throats, of general practice which were suitable for oral therapy. Ethical considerations did not allow inclusion of a control group treated with a placebo. The patients were assessed clinically, but for those with urinary tract infections the bacteriological response was also investigated. In each of the types of infections both dosages were equally effective. Irrespective of dosage, 90% of the whole group of patients improved by the third day, the response rates at the end of treatment were similar (87%) and the incidences of adverse reactions were not significantly different (11.5 % with 1 g./day and 10% with 2 g./day).

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