In vivo assessment of the sensitivity of Plasmodium falciparum to sulphadoxine/pyrimethamine combination (Fansidar) in six localities in Tanzania where chloroquine-resistant P. falciparum has been detected
- 1 January 1985
- journal article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 79 (4) , 482-483
- https://doi.org/10.1016/0035-9203(85)90071-9
Abstract
The sensitivity of Plasmodium falciparum strains to Fansidar (500 mg sulphadoxine/25 mg pyrimethamine) was tested in vivo in six localities in the United Republic of Tanzania where chloroquine-resistant P. falciparum strains have been demonstrated by both in vivo and in vitro tests. Single doses as recommended by the manufacturers achieved 100% clearance of parasitaemia in five localities with mean clearance period of between 2·2 and 2·9 days. In one locality (Gonja) the recommended dose failed to clear parasitaemia in two of the 38 cases (5·3%) within seven days. The possibility of using this drug combination for the treatment of chloroquine-resistant P. falciparum strains in the United Republic of Tanzania is discussed.Keywords
This publication has 2 references indexed in Scilit:
- In vivo and in vitro assessment of the sensitivity of Plasmodium falciparum to chloroquine in four districts of Tanga region, TanzaniaTransactions of the Royal Society of Tropical Medicine and Hygiene, 1985
- Chemoprophylaxis of malaria in Africa: the spent "magic bullet".BMJ, 1982