Enterohepatic Circulation of Carbon 4 of Cholesterol

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Abstract
The biliary C14-containing products derived from intraven. cholesterol-4-C14 were absorbed from the intestine and re-excreted into bile. 50% of the C14 so introduced into the duodeum found its way into bile within 4 hrs. of the time that its admn. was completed. The twice-excreted C14 was reabsorbed and re-excreted into bile a 3d time, this time to the extent of 90% of that introduced into the duodenum. Thus, an enterophepatic circulation in the metabolism of carbon 4 of cholesterol is demonstrated. In contrast to cholesterol, which is absorbed from the intestine via lymph, the biliary products of cholesterol metabolism are absorbed via portal blood.