Time Course of Free Radical Production After Primary Coronary Angioplasty for Acute Myocardial Infarction and the Effect of Vitamin C

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Abstract
Reactive oxygen species are thought to mediate reperfusion injury after rapid revascularization for acute myocardial infarction (AMI) and 8-epi prostaglandin (PG) F2 α, a free-radical catalyzed product of arachidonic acid, has been proposed as an indicator of oxidative stress in vivo during myocardial reperfusion. The time course of urinary 8-epi PGF2α excretion after primary coronary angioplasty (PTCA) for AMI was investigated, as well as the effect of prior administration of vitamin C. Urine samples, 1 before and 5 after primary PTCA (0-30, 30-60, 60-90, 90-120 and 120-150 min), were collected in 11 patients with AMI undergoing primary PTCA (Group 1), 10 patients with AMI treated with water-soluble vitamin C at an initial dose of 2.0 g followed by a constant infusion at 20 mg/min prior to primary PTCA (Group 2), and 6 patients with stable effort angina undergoing elective PTCA (Group 3). 8-epi PGF2 α was measured by enzyme immunoassay. There were no significant differences in urinary 8-epi PGF2 α excretion at baseline among the 3 groups. In Group 1, urinary 8-epi PGF2α excretion (ng/mmol creatinine) significantly increased from 60±8 at baseline to 122±16 at 60-90 min (pJpn Circ J 1999; 63: 924 - 928)