Conglobatin, a novel macrolide dilactone from Streptomyces conglobatus ATCC 31005.
- 1 January 1979
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 32 (9) , 874-877
- https://doi.org/10.7164/antibiotics.32.874
Abstract
Fermentation of deposited cultures of S. conglobatus, which produces the polyether antibiotic ionomycin, resulted in the isolation and characterization of a 2nd metabolite, conglobatin (C28H38N2O6).X-ray analysis revealed a dimeric macrolide dilactone structure for conglobatin similar to the structures of the mold metabolites vermiculin and pyrenophorin, from which the absolute configuration of conglobatin was inferred. The dimer consists of 2 molecules of 7-hydroxy-8-oxazoyl-2,4,6-trimethyl-2-octenoic acid joined by 2 ester linkages.This publication has 2 references indexed in Scilit:
- Characterization of ionomycin as a calcium ionophore.Journal of Biological Chemistry, 1978
- Ionomycin, a new polyether antibiotic.The Journal of Antibiotics, 1978