Effects of 5-hydroxytryptamine, fluoxetine and chlorimipramine on reflex bradycardia in rats
- 1 September 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 32 (1) , 493-496
- https://doi.org/10.1111/j.2042-7158.1980.tb12975.x
Abstract
In the urethane-anaesthetized rat, increasing 5-hydroxytryptaminergic receptor activity or functional 5-HT in brain with either the specific inhibitors of 5-HT reuptake (e.g. fluoxetine and chlorimipramine) or the 5-HT itself greatly reduced the reflex bradycardia induced by the systemically administered adrenaline. The data indicate that activation of central 5-HT-ergic receptors tends to inhibit reflex bradycardia.This publication has 9 references indexed in Scilit:
- Effects of brain monoamine depletion on chlorpromazine-induced hypothermia in rabbitsCanadian Journal of Physiology and Pharmacology, 1979
- Effects of specific inhibitors of 5‐hydroxytryptamine uptake on thermoregulation in rats.The Journal of Physiology, 1978
- Effect of an uptake inhibitor on serotonin metabolism in rat brain: Studies with 3-(p-trifluoromethylphenoxy)-n-methyl-3-phenylpropylamine (Lilly 110140)Life Sciences, 1974
- Participation of Central Serotonergic Neurons in the Control of the Circulation of the Unanesthetized RabbitCirculation Research, 1974
- A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-Trifluoromethylphenoxy)-n-methyl-3-phenylpropylamineLife Sciences, 1974
- EFFECTS OF P-CHLOROPHENYLALANINE ON BLOOD PRESSURE AND HEART RATE IN NORMAL RABBITS AND RABBITS WITH NEUROGENIC HYPERTENSIONClinical and Experimental Pharmacology and Physiology, 1974
- Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-α-ethyl-meta-tyramineEuropean Journal of Pharmacology, 1969
- The rat hypothalamus in stereotaxic coordinatesJournal of Comparative Neurology, 1959