NO EFFECT OF ANGIOTENSIN CONVERTING ENZYME-INHIBITION ON HEAVY PROTEINURIA IN DIABETIC NEPHROPATHY - A TRIAL OVER 6 MONTHS

  • 6 February 1988
    • journal article
    • research article
    • Vol. 118  (5) , 165-169
Abstract
The effect of angiotensin converting enzyme inhibition with captopril therapy (3.times.12.5 mg/d) on heavy proteinuria and kidney function was investigated in 10 insulin-treated diabetic patients over a period of 6 months. Urinary protein excretion increased from 3706 mg/day (SD 1491) to 5405 (SD 2699) after 6 months of treament (p = 0.05); serum creatinine rose from 248 .mu.mol/l (SD 163) to 283 (SD 186) (p<0.01), whereas there was no significant difference in blood pressure before (150/80 mm Hg-SD 23/6) and after therapy (150/90 mm Hg - SD23/10). HbA1c as a marker from 8.3% (SD 1.0) to 7.3% (SD 1.0) (p<0.05). - No beneficial effects of low dose angiotensin converting enzyme inhibition on heavy proteinuria could be demonstrated in this group of patients with advanced diabetic nephropathy. In particular, progressive deterioration of kidney function was not influenced by the captopril treatment. In diabetic patients with incipient diabetic nephropathy presenting with microalbuminuria, further studies concerning a possible therapeutic effect are necessary.