NEW ASPECTS OF THE MORPHOLOGY OF CIRCULATING MEGAKARYOCYTES IN RABBITS

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Abstract
Circulating cytoplasmatic megakaryocytes, isolated from central venous blood of rabbits by a saponin-hemolysis leuko-concentration technique, had 2 morphological appearances: a globular and an oblong form, referring to the shape of the cells as a whole and to the shape of the nuclei. The nucleus was either centrally or peripherally located. Of the megakaryocytes observed, 40% were cytoplasmatic and 60% naked nuclei. Regressive changes in the residual nucleus was observed, only 1.5% showing karyorrhexis or karyolysis. Megakaryoblasts and promegakaryocytes were never encountered. The average megakaryocyte content per ml central venous blood was 3.8 (range: 0-10). A not previously described cytoplasmatic-ligating process, in which the nucleus seemed to move out of the cytoplasm, forming a naked nucleus and leaving the total cytoplasm intact, was observed. This phenomenon was called nucleus escape. The function and fate of the intravascular megakaryocytes were briefly discussed.

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