Differential Effects of Dehydroepiandrosterone and Clofibrate on the Binding of 7,12-Dimethyl Benz(A)Anthracene to Hepatic DNA In Vivo - A Preliminary Study

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Abstract
The effects of feeding two compounds, dehydroeplandrosterone (DHEA), an adrenal steroid, and cloflbrate (CLOF) to rats (which are both hypolipidemic, hepatomegaly Inducing and hepatic peroxisome proliferating agents) on the binding of 7,12-dlmethylbenzU)-anthracene (DMBA) to hepatic DNA 1n vivo 1s compared. Male Sprague Dawley rats (two-three months old) were fed either DHEA or CLOF for 14 days at a dietary level of 0.8. Control rats were pair fed. An increase in liver weight followed by Increases per whole liver In total protein, without much change in DNA content was observed.

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