Induction of chromosome abnormalities in mouse and human epidermal keratinocytes by the human papillomavirus type 16 E7 oncogene
Open Access
- 1 July 1991
- journal article
- Published by Microbiology Society in Journal of General Virology
- Vol. 72 (7) , 1569-1577
- https://doi.org/10.1099/0022-1317-72-7-1569
Abstract
Cytogenetic abnormalities associated with human papillomavirus (HPV) type 16 were studied using primary human and mouse epidermal keratinocytes. The E7 transforming gene of HPV-16 was found to induce chromosome duplication in epidermal keratinocytes; little or no detectable chromosome disorganization was associated with the function of the E6 gene. These results suggest that the E7 gene-linked cytogenetic effect reflects HPV-16-associated pathogenicity in the early phase of transformation.Keywords
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