Protective Effects of Ketotifen on Guinea Pig Trachea
- 1 January 1984
- journal article
- research article
- Published by S. Karger AG in Respiration
- Vol. 45 (1) , 50-55
- https://doi.org/10.1159/000194597
Abstract
Effects were studied of ketotifen (Ke), an effective antiallergic drug, on guinea pig trachea. Ke (10-6-5 .times. 10-5 M) inhibits contractions induced in this preparation by acetylcholine, prostaglandin F2.alpha., BaCl2, KCl and electrical stimulation. Results suggest protective effects of Ke in airways. Ke exerts also a neural inhibitory effect on postganglionic parasympathetic fibers of guinea pig trachea. These findings resemble the effects reported previously for disodium cromoglycate and might be relevant for antiasthmatic and antiallergic properties of Ke.This publication has 6 references indexed in Scilit:
- Dissociation between the anti-anaphylactic and the anti-histaminic actions of ketotifenNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1981
- Pharmacological modulation of cholinergic neurotransmission in guinea pig trachea in vitroCanadian Journal of Physiology and Pharmacology, 1980
- A protective action of disodium cromoglycate against the contraction of guinea-pig ileum induced by various pharmacological stimulantsInflammation Research, 1980
- Preventive effect of ketotifen, a new antiallergic agent, on histamine‐induced bronchoconstriction in asthmaticsClinical and Experimental Allergy, 1979
- Clinical investigation of agents with prophylactic anti‐allergic effects in bronchial asthma*Clinical and Experimental Allergy, 1978
- CUMULATIVE DOSE-RESPONSE CURVES .1. INTRODUCTION TO TECHNIQUE1963