THE EFFECTS OF HALOTHANE, TRICHLOROETHYLENE AND ETHER ON THE HYPOXIC PRESSOR RESPONSE AND PULMONARY VASCULAR RESISTANCE IN THE ISOLATED, PERFUSED CAT LUNG

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Abstract
The pulmonary arterial pressor response to the inhalation of 3 per cent oxygen was tested in isolated cat lungs perfused in situ at constant flow. The pressor response could be elicited for periods up to 5 hours. The magnitude of the response was diminished during the inhalation of concentrations of halothane, trichloroethylene and ether which are used in clinical practice. Halothane produced a significant fall in pulmonary vascular resistance whereas trichloroethylene and ether produced no significant changes.