Gabapentin Increases the Hyperpolarization‐activated Cation Current Ih in Rat CA1 Pyramidal Cells
Open Access
- 6 February 2003
- Vol. 44 (2) , 150-156
- https://doi.org/10.1046/j.1528-1157.2003.36802.x
Abstract
Summary: Purpose: Gabapentin (GBP) is a commonly used drug in the treatment of partial seizures, but its mode of action is still unclear. The genesis of seizures in temporal lobe epilepsy is though...Keywords
This publication has 34 references indexed in Scilit:
- K+-induced changes in the properties of the hyperpolarization-activated cation current Ih in rat CA1 pyramidal cellsNeuroscience Letters, 2002
- Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendritesNature Neuroscience, 2002
- “Epileptic Neurons” in Temporal Lobe EpilepsyBrain Pathology, 2002
- Molecular and functional analysis of hyperpolarization‐activated pacemaker channels in the hippocampus after entorhinal cortex lesionThe FASEB Journal, 2001
- Molecular Diversity of Pacemaker Ion ChannelsAnnual Review of Physiology, 2001
- On The Cellular and Network Bases of Epileptic SeizuresAnnual Review of Physiology, 2001
- Anticonvulsants for Neuropathic Pain SyndromesDrugs, 2000
- Queer Current and Pacemaker: The Hyperpolarization-Activated Cation Current in NeuronsAnnual Review of Physiology, 1996
- The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the α2δ Subunit of a Calcium ChannelJournal of Biological Chemistry, 1996
- Zinc-Induced Collapse of Augmented Inhibition by GABA in a Temporal Lobe Epilepsy ModelScience, 1996