IODINE CONTENT OF AMNIOTIC-FLUID AND PLACENTAL-TRANSFER OF IODINATED DRUGS

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 53  (3) , 376-380
Abstract
Determinations of total I content, levels of thyroxine (T4) and triiodothyronine (T3), and protein concentrations were made on amniotic fluid. A total of 218 samples obtained at various stages of pregnancy from both normal and pathological pregnancies were studied. Normal values for the I and hormone concentrations are presented. Several amniotic fluid samples showed greatly elevated I levels, thought to be the result of maternal I intake. Such elevated levels can be produced by urography with an iodinated medium, by thyroid extract therapy and by vaginal therapy with an iodinated agent. Levels of T4 and T3 in amniotic fluid decreased slightly from the 2nd to the 3rd trimester and were unrelated to the total I levels. Despite reports in the literature of fetal hypothyroidism produced by amniography with a fat-soluble medium, no thyroid defect was observed in this series in the presence of elevated amniotic fluid I levels or when a water-soluble iodinated medium was used for amniography.

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