PHARMACOKINETICS OF HYDRALAZINE, APPARENT HYDRALAZINE AND HYDRALAZINE PYRUVIC-ACID HYDRAZONE IN HUMANS

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 26  (1) , 129-144
Abstract
Hydralazine is an antihypertensive vasodilator agent. Lack of specific assay techniques for its measurement have delayed elucidation of its pharmocokinetic profile. The plasma profiles of hydralazine, measured both by a specific and by a nonspecific assay were compared to a major plasma metabolite, hydralazine pyruvic acid hydrazone. After oral and i.v. administration of hydralazine, peak hydralazine levels were lower (7-33%) and plasma half lives [t1/2] were shorter (15-31%) when measured by the specific technique. The mean plasma t1/2 of the pyruvic acid hydrazone was 156 min and mean urinary clearance, 28 ml/min. The plasma profile of hydralazine and of the major metabolite, the pyruvic acid hydrazone, do not appear to correspond to the duration of antihypertensive effect of administered hydralazine.