Pathologic concentrations of interleukin 6 inhibit T cell responses via induction of activation of TGF‐β
- 1 August 1991
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 5 (11) , 2582-2585
- https://doi.org/10.1096/fasebj.5.11.1868982
Abstract
Interleukin 6 levels are increased in a variety of clinical conditions including bacterial and viral infections, HIV infection, autoimmune diseases, certain neoplasias, and traumatic injury. In general, all these conditions are characterized by suppression of one or more manifestations of the immune response. Concentrations of IL 6 comparable to those found in the sera of immunosuppressed, thermally injured patients selectively inhibit T cell proliferative responses. This suppression is independent of IL 2-mediated responses, is dependent on macrophage activity, and is reversed by antisera specific for transforming growth factor-β (TGF-β).—Zhou, D.; Munster, A.; Winchurch, R. A. Pathologic demonstrations of interleukin 6 inhibit T cell responses via induction of activation of TGF-β. FASEB J. 5: 2582-2585; 1991.Keywords
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