A serpin‐induced extensive proteolytic susceptibility of urokinase‐type plasminogen activator implicates distortion of the proteinase substrate‐binding pocket and oxyanion hole in the serpin inhibitory mechanism
Open Access
- 1 February 2001
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 268 (3) , 673-685
- https://doi.org/10.1046/j.1432-1327.2001.01921.x
Abstract
The formation of stable complexes between serpins and their target serine proteinases indicates formation of an ester bond between the proteinase active‐site serine and the serpin P1 residue [Egelund...Keywords
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