Spontaneous Hemorrhage Precipitated by an Emotional Stress Drug in Anticoagulant-Treated Rats

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Abstract
L.S.D. was used as an emotional stress agent in rats in an attempt to evaluate the influence of the central nervous system in triggering spontaneous hemorrhage in rats treated with anticoagulants. L.A. was used to evaluate whether the hemorrhagic activity of L.S.D. was through the pituitary-adrenal axis. A high percentage of spontaneous hemorrhage was found when the emotional stress agent was combined with the anticoagulant. There was no mortality or hemorrhagic manifestation with anticoagulant alone or in the groups where the treatments were given alone as a control. * Assisted by the Cardeza Foundation, Jefferson Medical College and Hospital, Philadelphia, Pennsylvania and by the United States Public Health Service Research Grant HE-04877. We are indebted to Dr. A. J. Erslev and Dr. L. B. Kazal of Cardeza Foundation for their interest and support.