Mild and Efficient Copper-Catalyzed Amination of Aryl Bromides with Primary Alkylamines
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- 21 February 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 5 (6) , 793-796
- https://doi.org/10.1021/ol0273396
Abstract
An efficient copper-catalyzed amination of aryl bromides with primary alkylamines was developed that uses commercially available diethylsalicylamide as the ligand. This amination reaction can be performed at 90 °C in good yield. A variety of functional groups are compatible with these reaction conditions. Preliminary results show that this reaction can be carried out under solvent-free conditions with comparable yields.Keywords
This publication has 19 references indexed in Scilit:
- Copper-catalyzed amination of aryl halides: single-step synthesis of triarylaminesTetrahedron Letters, 2002
- Aryl−Aryl Bond Formation One Century after the Discovery of the Ullmann ReactionChemical Reviews, 2002
- Formation of Aryl−Nitrogen, Aryl−Oxygen, and Aryl−Carbon Bonds Using Well-Defined Copper(I)-Based CatalystsOrganic Letters, 2001
- Formation of arylnitrogen bonds using a soluble copper(I) catalystTetrahedron Letters, 2001
- Catalytic amination of 5-iodouracil derivativesTetrahedron Letters, 2001
- An efficient copper-catalyzed coupling of aryl halides with imidazolesTetrahedron Letters, 1999
- Solid supported CN cross-coupling reactionsTetrahedron Letters, 1999
- Ligand-Accelerated Catalysis of the Ullmann Condensation: Application to Hole Conducting TriarylaminesThe Journal of Organic Chemistry, 1998
- Palladium-Catalyzed Coupling of Optically Active Amines with Aryl BromidesJournal of the American Chemical Society, 1997
- Synthese des Phen‐β‐phenyl‐α‐oxymiazinsEuropean Journal of Inorganic Chemistry, 1903