The synthesis of adrenaline crown ethers

Abstract
The syntheses of adrenaline-15-crown-5 and adrenaline-18-crown-6 starting from acetovanillone are reported, together with the properties of these compounds. Alkali and alkaline-earth metal complexes of these ligands have been prepared. A method of separating crown ethers based on their preferential complexation of barium is discussed.

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