The acetylcholine receptor: Its molecular biology and biotechnological prospects
- 5 February 1989
- Vol. 10 (2-3) , 48-54
- https://doi.org/10.1002/bies.950100204
Abstract
The structure and behaviour of the acetylcholine receptor (AChR) is described, and the evidence that it is an allosteric protein is discussed. The genes for the AChR subunits are subject to a complex set of spatio‐temporal transcriptional controls during development of the motor endplate, and these findings are reviewed here. Finally, the biotechnological prospects suggested by the new data are noted.Keywords
This publication has 46 references indexed in Scilit:
- Activity-dependent regulation of gene expression in muscle and neuronal cellsMolecular Neurobiology, 1989
- Arrangement of the acetylcholine receptor subunits in the resting and desensitized states, determined by cryoelectron microscopy of crystallized Torpedo postsynaptic membranes.The Journal of cell biology, 1988
- Differential regulation of muscle acetylcholine receptor γ‐and ϵ‐subunit mRNAsFEBS Letters, 1987
- Calcitonin gene-related peptide and muscle activity regulate acetylcholine receptor alpha-subunit mRNA levels by distinct intracellular pathways.The Journal of cell biology, 1987
- Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: [3H]chlorpromazine labels homologous residues in the .beta. and .delta. chainsBiochemistry, 1987
- The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunitsFEBS Letters, 1986
- Nicotinic acetylcholine receptors in vertebrate muscle: Properties, distribution and neural controlProgress in Neurobiology, 1985
- Rapid kinetics of agonist binding and permeability response analyzed in parallel on acetylcholine receptor rich membranes from Torpedo marmorataBiochemistry, 1983
- Multiple sites of action for noncompetitive blockers on acetylcholine receptor rich membrane fragments from Torpedo marmorataBiochemistry, 1983
- Structural homology of Torpedo californica acetylcholine receptor subunitsNature, 1983