Catalytic hydrolysis of cAMP
- 1 August 1987
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 65 (8) , 1882-1884
- https://doi.org/10.1139/v87-315
Abstract
[Co(trien)(OH2)(OH)]Cl2 is highly efficient in catalyzing the hydrolysis of cAMP to adenosine in neutral water (6 × 10−6 M−1 s−1 at 50 °C). The cobalt complex promoted hydrolysis of cAMP is estimated to be about a hundred million times faster than the uncatalyzed hydrolysis of cAMP. In the time that [Co(trien)(OH2)(OH)]Cl2 produces 50% cleavage of cAMP, [Co(en)2(NH3)(OH)]Cl2 or ZnCl2 has no observable effect on the hydrolysis of cAMP. A detailed mechanism is presented for the cobalt complex promoted hydrolysis of the phosphodiester.This publication has 7 references indexed in Scilit:
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